Science

One of the most studied probiotics in the world

BioGaia’s probiotic products with L. reuteri are among the most scientifically well-documented probiotics in the world with regard to both efficacy and safety.

BioGaia’s different strains of L. reuteri have been studied in more than 290 clinical trials involving over 25,000 people of all ages (Dec 2025).

Studies have been performed on the following:

  • Infantile colic and digestive health in children
  • Immune modulation and infection protection
  • Respiratory infections
  • Antibiotic-associated side effects, such as diarrhea
  • Adjunctive treatment of Helicobacter pylori infection
  • Acute diarrhea
  • Oral health, such as gingivitis and periodontitis
  • Irritable bowel syndrome (IBS)
  • Osteopenia
  • Autism spectrum condition
  • Urinary tract infections

Clinical studies

What is EvidenceBiotics™?

EvidenceBiotics™ is BioGaia’s new premium classification for probiotics that meet the highest standards of quality, safety, and clinical validation. It represents our commitment to providing science-backed solutions that consumers and healthcare professionals can trust.
Uncompromising Quality:  All BioGaia products are classified with EvidenceBiotics™ ensuring they are manufactured according to stringent industry standards and undergoes comprehensive quality testing. From production to packaging, every step is designed to ensure the highest level of safety and consistency.
CFU Protection Technology: Maintaining the viability of beneficial bacteria is critical for effectiveness. Our proprietary CFU Protection Technology uses advanced moisture, absorbing methods and innovative production techniques to protect live bacteria, ensuring that every product delivers the minimum number of active cultures stated on the packaging.
Clinically Proven and Trusted: EvidenceBiotics™ is supported by a robust body of clinical evidence. With over 290 published studies involving more than 25,000 patients across all ages, these probiotics demonstrate proven safety, efficacy, and reliable results.
Guided by Science: The EvidenceBiotics™ classification helps guide consumers toward probiotics that are not only high-quality and effective but also grounded in rigorous scientific research-making it easier for healthcare professionals and consumers to make informed decisions.

Clinical trials supporting the use of BioGaia probiotics ​

L. reuteri Protectis, Prodentis, Pharax, Gastrus and Osfortis

61

studies in 7,873 subjects

Infants 0-12 months

31

studies in 4,290 subjects

Toddlers 13-36 months

47

studies in 4,657 subjects

Children 3-18 years

156

studies in 8,185 subjects

Adults >18 years

Research on bacteria

In the past decade, research on bacteria and their significance to our health has increased. At BioGaia, we have been researching Limosilactobacillus reuteri (formerly Lactobacillus reuteri) for more than 35 years. During the years, we built a unique research network of specialists at research institutes worldwide. Together we have learned and gained knowledge about several L. reuteri bacteria strains for various conditions.

Our Research Network

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